Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors

BACKGROUND AND PURPOSE: Ca(2+)-calmodulin (Ca(2+)CaM) is widely accepted as an inhibitor of cardiac ryanodine receptors (RyR2); however, the effects of physiologically relevant CaM concentrations have not been fully investigated. EXPERIMENTAL APPROACH: We investigated the effects of low concentratio...

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Détails bibliographiques
Auteurs principaux: Sigalas, C, Bent, S, Kitmitto, A, O'Neill, S, Sitsapesan, R
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2009
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697758/
https://ncbi.nlm.nih.gov/pubmed/19220289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00092.x
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