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Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines

BACKGROUND AND PURPOSE: Prostaglandin (PG) E(2) and interleukin (IL)-8 are simultaneously increased during the inflammation that characterizes numerous pathologies such as inflammatory bowel disease. IL-8 is a potent neutrophil chemo-attractant and activator, and can initiate and/or exacerbate tissu...

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Autores principales: Dey, I, Giembycz, MA, Chadee, K
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697677/
https://ncbi.nlm.nih.gov/pubmed/19175605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00056.x
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