Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
Several groups have attempted to develop gene therapy strategies to treat cancer via introduction of the wild-type (wt) p53 cDNA into cancer cells. Unfortunately, these approaches do not result in regulated expression of the p53 gene and do not reduce expression of the mutant p53 that is overexpress...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890910/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.150104097 |
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