V(D)J recombination is not activated by demethylation of the kappa locus
V(D)J recombination is thought to be regulated by changes in the accessibility of target sites, such as modulation of methylation. To test whether demethylation of the kappa locus can activate recombination, we generated two recombinationally active B cell lines in which the gene for maintenance of...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880575/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.150218497 |
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