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Induction of HIF-1α Expression by Intermittent Hypoxia: Involvement of NADPH Oxidase, Ca(2+) Signaling, Prolyl Hydroxylases, and mTOR
Sleep-disordered breathing with recurrent apnea (periodic cessation of breathing) results in chronic intermittent hypoxia (IH), which leads to cardiovascular and respiratory pathology. Molecular mechanisms underlying IH-evoked cardio-respiratory co-morbidities have not been delineated. Mice with het...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2696817/ https://ncbi.nlm.nih.gov/pubmed/18651560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21537 |
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