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Targeting of Adenovirus Serotype 5 Pseudotyped with Short Fiber from Serotype 41 to c-erbB2-Positive Cells Using Bispecific Single-Chain Diabody

The purpose of the current study was to alter the broad native tropism of human adenovirus for virus targeting to c-erbB2-positive cancer cells. First, we engineered a single-chain antibody (scFv) against the c-erbB2 oncoprotein into minor capsid protein IX (pIX) of adenovirus serotype 5 (Ad5) in a...

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Main Authors: Kashentseva, Elena A., Douglas, Joanne T., Zinn, Kurt R., Curiel, David T., Dmitriev, Igor P.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696239/
https://ncbi.nlm.nih.gov/pubmed/19285990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.016
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