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Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery

Ebola Zaire virus is highly pathogenic for humans, with case fatality rates approaching 90% in large outbreaks in Africa. The virus replicates in macrophages and dendritic cells (DCs), suppressing production of type I interferons (IFNs) while inducing the release of large quantities of proinflammato...

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Bibliografiske detaljer
Main Authors: Chang, Tsung-Hsien, Kubota, Toru, Matsuoka, Mayumi, Jones, Steven, Bradfute, Steven B., Bray, Mike, Ozato, Keiko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696038/
https://ncbi.nlm.nih.gov/pubmed/19557165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000493
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