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Ebola Virus-Like Particles Stimulate Type I Interferons and Proinflammatory Cytokine Expression Through the Toll-Like Receptor and Interferon Signaling Pathways

Ebola viruses (EBOV) can cause severe hemorrhagic disease with high case fatality rates. Currently, no vaccines or therapeutics are approved for use in humans. Ebola virus-like particles (eVLP) comprising of virus protein (VP40), glycoprotein, and nucleoprotein protect rodents and nonhuman primates...

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Autors principals: Ayithan, Natarajan, Bradfute, Steven B., Anthony, Scott M., Stuthman, Kelly S., Dye, John M., Bavari, Sina, Bray, Mike, Ozato, Keiko
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924795/
https://ncbi.nlm.nih.gov/pubmed/24102579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2013.0035
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