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Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma

Constitutive activation of the insulin-like growth factor (IGF)-signaling axis is frequently observed in human hepatocellular carcinoma (HCC). Especially the overexpression of the fetal growth factor IGF-II, IGF-Ireceptor (IGF-IR), and cytoplasmic downstream effectors such as insulin-receptor substr...

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Detalhes bibliográficos
Main Authors: Breuhahn, Kai, Schirmacher, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The WJG Press and Baishideng 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695909/
https://ncbi.nlm.nih.gov/pubmed/18350600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.14.1690
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