Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo

AIM: To generate an adenoviral vector specifically targeting the EphA2 receptor (EphA2R) highly expressed on pancreatic cancer cells in vivo. METHODS: YSA, a small peptide ligand that binds the EphA2R with high affinity, was inserted into the HI loop of the adenovirus serotype 5 fiber knob. To furth...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: van Geer, Michael A, Bakker, Conny T, Koizumi, Naoya, Mizuguchi, Hiroyuki, Wesseling, John G, Oude Elferink, Ronald PJ, Bosma, Piter J
Format: Artigo
Sprache:Inglês
Veröffentlicht: The WJG Press and Baishideng 2009
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Brief Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695891/
https://ncbi.nlm.nih.gov/pubmed/19522026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.15.2754
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