MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses

MyD88 KO (knockout) mice are exquisitely sensitive to CNS (central nervous system) infection with Staphylococcus aureus, a common aetiological agent of brain abscess, exhibiting global defects in innate immunity and exacerbated tissue damage. However, since brain abscesses are typified by the involv...

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Autors principals: Garg, Sarita, Nichols, Jessica R, Esen, Nilufer, Liu, Shuliang, Phulwani, Nirmal K, Syed, Mohsin Md., Wood, William H, Zhang, Yongqing, Becker, Kevin G, Aldrich, Amy, Kielian, Tammy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Neurochemistry 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695586/
https://ncbi.nlm.nih.gov/pubmed/19570030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20090004
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