Bombesin marine toxin conjugates inhibit the growth of lung cancer cells

Hemiasterlin (Hem) and dolastatin (Dol) are marine natural products which are cytotoxic for cancer cells. Hem, a tripeptide, and Dol, a hexapeptide, were conjugated with linkers (L) to the universal BB agonist DPhe-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH(2)(BA1) and the effects of the Hem-BB and Dol-BB...

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Detalhes bibliográficos
Main Authors: Moody, Terry W., Pradhan, Tapas, Mantey, Samuel A., Jensen, Robert T., Dyba, Marcin, Moody, Deborah, Tarasova, Nadya I., Michejda, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695325/
https://ncbi.nlm.nih.gov/pubmed/18336841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2008.01.019
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