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Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
The p53tumour suppressor is regulated mainly by Mdm2, an E3 ubiquitin ligase that promotes the ubiquitylation and proteasome-mediated degradation of p53. Many agents that induce p53 are inhibitors of transcription, suggesting that the p53 pathway can detect a signal(s) arising from transcriptional m...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2695134/ https://ncbi.nlm.nih.gov/pubmed/17237821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210209 |
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