A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo

Resistance to thyroid hormone (RTH) is most often due to point mutations in the β-isoform of the thyroid hormone (TH) receptor (TR-β). The majority of mutations involve the ligand-binding domain, where they block TH binding and receptor function on both stimulatory and inhibitory TH response element...

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Autores principales: Machado, Danielle S., Sabet, Amin, Santiago, Leticia A., Sidhaye, Aniket R., Chiamolera, Maria I., Ortiga-Carvalho, Tania M., Wondisford, Fredric E.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695112/
https://ncbi.nlm.nih.gov/pubmed/19439650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903227106
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