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Engineering botulinum neurotoxin to extend therapeutic intervention

Clostridium botulinum neurotoxins (BoNTs) are effective therapeutics for a variety of neurological disorders, such as strabismus, blepharospam, hemificial spasm, and cervical dystonia, because of the toxin's tropism for neurons and specific cleavage of neuronal soluble N-ethylmaleimide-sensitiv...

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Autors principals: Chen, Sheng, Barbieri, Joseph T.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695098/
https://ncbi.nlm.nih.gov/pubmed/19487672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903111106
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