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Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

Human IgM(+)IgD(+)CD27(+) B cells have mutated Ig genes and harbor a splenic marginal zone phenotype. The group of R. Küppers has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-exp...

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Detalhes bibliográficos
Main Authors: Weller, Sandra, Reynaud, Claude-Agnès, Weill, Jean-Claude
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley-VCH 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694967/
https://ncbi.nlm.nih.gov/pubmed/16180256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200535446
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