Leishmania infantum sterol 24-c-methyltransferase formulated with MPL-SE induces cross-protection against L. major infection

The enzyme sterol 24-c-methyltranferase (SMT) is required for the biosynthesis of ergosterol, the major membrane sterol in Leishmania parasites. SMT and ergosterol are not found in mammals, so this protein may be an attractive target for anti-leishmanial vaccines and drugs. We have previously demons...

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Autors principals: Goto, Yasuyuki, Bhatia, Ajay, Raman, Vanitha S., Vidal, Silvia E. Z., Bertholet, Sylvie, Coler, Rhea N., Howard, Randall F., Reed, Steven G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694840/
https://ncbi.nlm.nih.gov/pubmed/19428898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.02.079
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