BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

Eitemau Tebyg

• Wnt Inhibitors Dkk1 and Sost Are Downstream Targets of BMP Signaling Through the Type IA Receptor (BMPRIA) in Osteoblasts
  gan: Kamiya, Nobuhiro, et al.
  Cyhoeddwyd: (2010)
• Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass
  gan: Kamiya, Nobuhiro, et al.
  Cyhoeddwyd: (2008)
• Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1
  gan: Kamiya, Nobuhiro, et al.
  Cyhoeddwyd: (2011)
• Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass
  gan: Kamiya, Nobuhiro, et al.
  Cyhoeddwyd: (2020)
• New insights on the roles of BMP signaling in bone – A review of recent mouse genetic studies
  gan: Kamiya, Nobuhiro, et al.
  Cyhoeddwyd: (2011)