BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

Bone morphogenetic proteins (BMPs) are known to induce ectopic bone. However, it is largely unknown how BMP signaling in osteoblasts directly regulates endogenous bone. This study investigated the mechanism by which BMP signaling through the type IA receptor (BMPR1A) regulates endogenous bone mass u...

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Detalhes bibliográficos
Main Authors: Kamiya, Nobuhiro, Ye, Ling, Kobayashi, Tatsuya, Mochida, Yoshiyuki, Yamauchi, Mitsuo, Kronenberg, Henry M., Feng, Jian Q., Mishina, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694443/
https://ncbi.nlm.nih.gov/pubmed/18927151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.025825
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