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BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

Bone morphogenetic proteins (BMPs) are known to induce ectopic bone. However, it is largely unknown how BMP signaling in osteoblasts directly regulates endogenous bone. This study investigated the mechanism by which BMP signaling through the type IA receptor (BMPR1A) regulates endogenous bone mass u...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kamiya, Nobuhiro, Ye, Ling, Kobayashi, Tatsuya, Mochida, Yoshiyuki, Yamauchi, Mitsuo, Kronenberg, Henry M., Feng, Jian Q., Mishina, Yuji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694443/
https://ncbi.nlm.nih.gov/pubmed/18927151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.025825
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