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Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis

Biosynthesis of the leukotriene A (LTA) class of epoxide is a lipoxygenase-catalyzed transformation requiring a fatty acid hydroperoxide substrate containing at least three double bonds. Here, we report on biosynthesis of a dienoic analog of LTA epoxides via a different enzymatic mechanism. Beginnin...

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Hlavní autoři: Niisuke, Katrin, Boeglin, William E., Murray, John J., Schneider, Claus, Brash, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694342/
https://ncbi.nlm.nih.gov/pubmed/19244216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900025-JLR200
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