The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice

We examined mechanisms by which L-4F reduces obesity and diabetes in obese (ob) diabetic mice. We hypothesized that L-4F reduces adiposity via increased pAMPK, pAKT, HO-1, and increased insulin receptor phosphorylation in ob mice. Obese and lean mice were divided into five groups: lean, lean-L-4F-tr...

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Détails bibliographiques
Auteurs principaux: Peterson, Stephen J., Kim, Dong Hyun, Li, Ming, Positano, Vincenzo, Vanella, Luca, Rodella, Luigi F., Piccolomini, Francesco, Puri, Nitin, Gastaldelli, Amalia, Kusmic, Claudia, L'Abbate, Antonio, Abraham, Nader G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694329/
https://ncbi.nlm.nih.gov/pubmed/19224872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800610-JLR200
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