TRPV4-DEFICIENT MICE EXHIBIT IMPAIRED ENDOTHELIUM-DEPENDENT RELAXATION INDUCED BY ACETYLCHOLINE IN VITRO AND IN VIVO

Agonist-induced Ca(2+) entry is important for the synthesis and release of vasoactive factors in endothelial cells. The transient receptor potential vanilloid type 4 (TRPV4) channel, a Ca(2+)-permeant cation channel, is expressed in endothelial cells and involved in the regulation of vascular tone....

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Bibliographische Detailangaben
Hauptverfasser: Zhang, David X., Mendoza, Suelhem A., Bubolz, Aaron H., Mizuno, Atsuko, Ge, Zhi-Dong, Li, Rongshan, Warltier, David C., Suzuki, Makoto, Gutterman, David D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694062/
https://ncbi.nlm.nih.gov/pubmed/19188524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.108.127100
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