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A cytotoxic ribonuclease which specifically cleaves four isoaccepting arginine tRNAs at their anticodon loops

Colicin D has long been thought to stop protein synthesis in infected Escherichia coli cells by inactivating ribosomes, just like colicin E3. Here, we show that colicin D specifically cleaves tRNAs(Arg) including four isoaccepting molecules both in vivo and in vitro. The cleavage occurs in vitro bet...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tomita, Kozo, Ogawa, Tetsuhiro, Uozumi, Takeshi, Watanabe, Kimitsuna, Masaki, Haruhiko
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26938/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880568/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140213797
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