Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells

BACKGROUND: Treatment options for metastatic renal cell carcinoma (RCC) are limited due to resistance to chemo- and radiotherapy. The development of small-molecule multikinase inhibitors has now opened novel treatment options. We evaluated the influence of the receptor tyrosine kinase inhibitor AEE7...

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Main Authors: Juengel, Eva, Engler, Johanna, Natsheh, Iyad, Jones, Jon, Mickuckyte, Ausra, Hudak, Lukasz, Jonas, Dietger, Blaheta, Roman A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693528/
https://ncbi.nlm.nih.gov/pubmed/19473483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-161
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