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Analysis of Full and Partial Agonists Binding to β(2)-Adrenergic Receptor Suggests a Role of Transmembrane Helix V in Agonist-Specific Conformational Changes
The 2.4 Å crystal structure of the β(2)-adrenergic receptor (β(2)AR) in complex with the high-affinity inverse agonist (-)-carazolol provides a detailed structural framework for the analysis of ligand recognition by adrenergic receptors. Insights into agonist binding and the corresponding conformati...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693451/ https://ncbi.nlm.nih.gov/pubmed/19353579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.949 |
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