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RASGRP1 OVEREXPRESSION IN THE EPIDERMIS OF TRANSGENIC MICE CONTRIBUTES TO TUMOR PROGRESSION DURING MULTISTAGE SKIN CARCINOGENESIS

RasGRP1 is a guanine nucleotide exchange factor for Ras, activated in response to the second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters. We have previously shown that RasGRP1 is expressed in mouse epidermal keratinocytes and that transgenic mice overexpressing RasGRP1...

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Detalhes bibliográficos
Main Authors: Luke, Courtney T., Oki-Idouchi, Carolyn E., Cline, J. Mark, Lorenzo, Patricia S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693226/
https://ncbi.nlm.nih.gov/pubmed/17974959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-2375
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