Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

To assess the effect of transforming growth factor beta 1 on the skin in vivo, we have targeted its expression to the epidermis of transgenic mice. To ensure that active TGF-beta 1 was expressed, we used a porcine TGF-beta 1 cDNA with mutations of Cys-223-->Ser and Cys-225-->Ser, which allow c...

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Detalhes bibliográficos
Main Authors: Sellheyer, K, Bickenbach, J R, Rothnagel, J A, Bundman, D, Longley, M A, Krieg, T, Roche, N S, Roberts, A B, Roop, D R
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC46691/
https://ncbi.nlm.nih.gov/pubmed/7685120
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