Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

To assess the effect of transforming growth factor beta 1 on the skin in vivo, we have targeted its expression to the epidermis of transgenic mice. To ensure that active TGF-beta 1 was expressed, we used a porcine TGF-beta 1 cDNA with mutations of Cys-223-->Ser and Cys-225-->Ser, which allow constit...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sellheyer, K, Bickenbach, J R, Rothnagel, J A, Bundman, D, Longley, M A, Krieg, T, Roche, N S, Roberts, A B, Roop, D R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46691/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7685120/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5237
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