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Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

The Sir2 family of proteins are broadly conserved NAD(+)-dependant deacetylases that are implicated in diverse biological processes including DNA regulation, metabolism and longevity. Sir2 proteins are regulated in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that...

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Bibliografski detalji
Glavni autori: Sanders, Brandi D., Zhao, Kehao, Slama, James T., Marmorstein, Ronen
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693224/
https://ncbi.nlm.nih.gov/pubmed/17289592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.12.022
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