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Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes
The Sir2 family of proteins are broadly conserved NAD(+)-dependant deacetylases that are implicated in diverse biological processes including DNA regulation, metabolism and longevity. Sir2 proteins are regulated in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693224/ https://ncbi.nlm.nih.gov/pubmed/17289592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.12.022 |
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