Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen αGalCer

Short or polyunsaturated lipid variants of the NKT cell antigen α-galactosylceramide (αGC) exhibit decreased potency and a Th2 bias in vivo despite conserved TCR contact residues and stable binding to CD1d at neutral and acidic pH. Using reagents to directly visualize lipids in their free or CD1d-bo...

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Detalhes bibliográficos
Main Authors: Bai, Li, Sagiv, Yuval, Liu, Yang, Freigang, Stefan, Yu, Karl O. A., Teyton, Luc, Porcelli, Steven A., Savage, Paul B., Bendelac, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693181/
https://ncbi.nlm.nih.gov/pubmed/19506241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901228106
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