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PROTEOLYTIC PROCESSING OF DELTA-LIKE 1 BY ADAM PROTEASES
Delta-like 1 (Dll1) is a mammalian ligand for Notch receptors. Interactions between Dll1 and Notch in trans activate the Notch pathway, whereas Dll1 binding to Notch in cis inhibits Notch signaling. Dll1 undergoes proteolytic processing in its extracellular domain by ADAM10. In this work, we demonst...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado: |
2006
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Assuntos: | |
Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692894/ https://ncbi.nlm.nih.gov/pubmed/17107962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M605451200 |
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