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ADAM Proteases: Ligand Processing and Modulation of the Notch Pathway
ADAM metalloproteases play important roles in development and disease. One of the key functions of ADAMs is the proteolytic processing of Notch receptors and their ligands. ADAM-mediated cleavage of Notch represents the first step of the regulated intramembrane proteolysis of the receptor, leading t...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674646/ https://ncbi.nlm.nih.gov/pubmed/18344021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-008-7586-4 |
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