Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis

Cardiolipin (CL), a unique mitochondrial phospholipid synthesized by CL synthase (CLS), plays important, yet not fully understood, roles in mitochondria-dependent apoptosis. We manipulated CL levels in HeLa cells by knocking down CLS using RNA interference and selected a clone of CL-deficient cells...

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Bibliografiske detaljer
Main Authors:	Huang, Zhentai, Jiang, Jianfei, Tyurin, Vladimir A., Zhao, Qing, Mnuskin, Alexandra, Ren, Jin, Belikova, Natalia A., Feng, Weihong, Kurnikov, Igor V., Kagan, Valerian E.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2008
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2692820/ https://ncbi.nlm.nih.gov/pubmed/18375209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.02.016
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Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis

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