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Regulation of Bax by c-Jun NH(2)-terminal kinase and Bcl-xL in vinblastine-induced apoptosis
Microtubule inhibitors, such as vinblastine, are widely used in cancer chemotherapy. Vinblastine exerts its antitumor effect by inducing apoptosis. In KB-3 cells, we have shown previously that vinblastine activates c-Jun NH(2)-terminal protein kinase (JNK) and causes Bax mitochondrial translocation...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692743/ https://ncbi.nlm.nih.gov/pubmed/19427996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.04.005 |
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