Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia–reperfusion injury

Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia-reperfusion injury suggesting that receptor activation is protective in vivo. Here we tested this hypothesis by expressing the human-A(1)AR in A(1)AR knockout mice. Renal ischemia-reperfusion was induced i...

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Main Authors: Kim, Minjae, Chen, Sean W.C., Park, Sang Won, Kim, Mihwa, D’Agati, Vivette D., Yang, Jay, Lee, H. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692553/
https://ncbi.nlm.nih.gov/pubmed/19190680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2008.699
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