Synthesis of 1-β-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus

There are no FDA approved drugs for the treatment of hemorrhagic fever with renal syndrome (HFRS), a serious human illnesses caused by hantaviruses. Clinical studies using ribavirin (RBV) to treat HFRS patients suggest that it provides an improved prognosis when given early in the course of disease....

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Main Authors: Chung, Dong-Hoon, Kumarapperuma, Sidath C., Sun, Yanjie, Li, Qianjun, Chu, Yong-Kyu, Arterburn, Jeffrey B., Parker, William B., Smith, Jeffrey, Spik, Kristin, Ramanathan, Harish, Schmaljohn, Connie S., Jonsson, Colleen B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692291/
https://ncbi.nlm.nih.gov/pubmed/18394724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.02.003
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