A novel nucleoside analog, 1-β-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole (ETAR), exhibits efficacy against a broad range of flaviviruses in vitro

Antiviral therapies are urgently needed to control emerging flaviviruses such as dengue, West Nile, and yellow fever. Ribavirin (RBV) has shown activity against flaviviruses in cultured cells, but efficacy in animal models has generally been poor. In a preliminary screen of novel, synthetic 1-β-D-ri...

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Main Authors: McDowell, Michael, Gonzales, Sarah R., Kumarapperuma, Sidath C., Jeselnik, Marjan, Arterburn, Jeffrey B., Hanley, Kathryn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892036/
https://ncbi.nlm.nih.gov/pubmed/20416341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2010.04.007
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