Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

The tenovins and cambinol are two classes of sirtuin inhibitor that exhibit antitumor activity in preclinical models. This report describes modifications to the core structure of cambinol, in particular by incorporation of substitutents at the N1-position, which lead to increased potency and modifie...

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Bibliographic Details
Main Authors: Medda, Federico, Russell, Rupert J. M., Higgins, Maureen, McCarthy, Anna R., Campbell, Johanna, Slawin, Alexandra M. Z., Lane, David P., Lain, Sonia, Westwood, Nicholas J.
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691587/
https://ncbi.nlm.nih.gov/pubmed/19419202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8014298
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