Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis

BACKGROUND: Recombinant adenovirus-vectored (Ad) tuberculosis (TB) vaccine platform has demonstrated great potential to be used either as a stand-alone or a boost vaccine in murine models. However, Ad TB vaccine remains to be evaluated in a more relevant and sensitive guinea pig model of pulmonary T...

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Bibliographic Details
Main Authors: Xing, Zhou, McFarland, Christine T., Sallenave, Jean-Michel, Izzo, Angelo, Wang, Jun, McMurray, David N.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689939/
https://ncbi.nlm.nih.gov/pubmed/19516906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005856
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