Cigarette Smoke Impairs Clearance of Apoptotic Cells through Oxidant-dependent Activation of RhoA

Rationale: Cigarette smoke (CS) is the primary cause of chronic obstructive pulmonary disease (COPD), an effect that is, in part, due to intense oxidant stress. Clearance of apoptotic cells (efferocytosis) is a critical regulator of lung homeostasis, which is defective in smokers and in patients wit...

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Detalhes bibliográficos
Main Authors: Richens, Tiffany R., Linderman, Derek J., Horstmann, Sarah A., Lambert, Cherie, Xiao, Yi-Qun, Keith, Robert L., Boé, Darren M., Morimoto, Konosuke, Bowler, Russell P., Day, Brian J., Janssen, William J., Henson, Peter M., Vandivier, R. William
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2009
Assuntos:
B. Chronic Obstructive Pulmonary Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689911/
https://ncbi.nlm.nih.gov/pubmed/19264974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200807-1148OC
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