High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

Replication and pathogenesis of the human immunodeficiency virus (HIV) is tightly linked to the structure of its RNA genome, but genome structure in infectious virions is poorly understood. We invent high-throughput SHAPE (selective 2′-hydroxyl acylation analyzed by primer extension) technology, whi...

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Autors principals: Wilkinson, Kevin A, Gorelick, Robert J, Vasa, Suzy M, Guex, Nicolas, Rein, Alan, Mathews, David H, Giddings, Morgan C, Weeks, Kevin M
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689691/
https://ncbi.nlm.nih.gov/pubmed/18447581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060096
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