High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

Replication and pathogenesis of the human immunodeficiency virus (HIV) is tightly linked to the structure of its RNA genome, but genome structure in infectious virions is poorly understood. We invent high-throughput SHAPE (selective 2′-hydroxyl acylation analyzed by primer extension) technology, whi...

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Detalhes bibliográficos
Main Authors: Wilkinson, Kevin A, Gorelick, Robert J, Vasa, Suzy M, Guex, Nicolas, Rein, Alan, Mathews, David H, Giddings, Morgan C, Weeks, Kevin M
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689691/
https://ncbi.nlm.nih.gov/pubmed/18447581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060096
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