Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

Duchenne muscular dystrophy (DMD) is an X-linked, degenerative muscle disease that is exacerbated by secondary inflammation. Here, we characterized the immunological milieu of dystrophic muscle in mdx mice, a model of DMD, to identify potential therapeutic targets. We identified a specific subpopula...

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Detalhes bibliográficos
Main Authors: Vetrone, Sylvia A., Montecino-Rodriguez, Encarnacion, Kudryashova, Elena, Kramerova, Irina, Hoffman, Eric P., Liu, Scot D., Miceli, M. Carrie, Spencer, Melissa J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689112/
https://ncbi.nlm.nih.gov/pubmed/19451692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37662
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