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Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice
Bim, the B cell lymphoma 2–interacting (Bcl2-interacting) mediator, maintains immunological tolerance by deleting autoreactive lymphocytes through apoptosis. We report here that Bim is also, paradoxically, required for the activation of autoreactive T cells. Deletion of Bim in hematopoietic cells re...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2689102/ https://ncbi.nlm.nih.gov/pubmed/19411758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37619 |
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