Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice

Bim, the B cell lymphoma 2–interacting (Bcl2-interacting) mediator, maintains immunological tolerance by deleting autoreactive lymphocytes through apoptosis. We report here that Bim is also, paradoxically, required for the activation of autoreactive T cells. Deletion of Bim in hematopoietic cells re...

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Bibliographic Details
Main Authors: Ludwinski, Maciej W., Sun, Jing, Hilliard, Brendan, Gong, Shunyou, Xue, Fan, Carmody, Ruaidhri J., DeVirgiliis, Jennifer, Chen, Youhai H.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689102/
https://ncbi.nlm.nih.gov/pubmed/19411758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37619
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