TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

Aberrant methylation of tumor suppressor genes can lead to their silencing in many cancers. TSC-22 is a gene silenced in several solid tumors, but its function and the mechanism(s) responsible for its silencing are largely unknown. Here we demonstrate that the TSC-22 promoter is methylated in primar...

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Opis bibliograficzny
Główni autorzy: Yu, Jianhua, Ershler, Maxim, Yu, Li, Wei, Min, Hackanson, Björn, Yokohama, Akihiko, Mitsui, Takeki, Liu, Chunhui, Mao, Hsiaoyin, Liu, Shujun, Liu, Zhongfa, Trotta, Rossana, Liu, Chang-gong, Liu, Xiuping, Huang, Kun, Visser, Jan, Marcucci, Guido, Plass, Christoph, Belyavsky, Alexander V., Caligiuri, Michael A.
Format: Artigo
Język:Inglês
Wydane: American Society of Hematology 2009
Hasła przedmiotowe:
Lymphoid Neoplasia
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689053/
https://ncbi.nlm.nih.gov/pubmed/19329776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-205732
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