TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

Aberrant methylation of tumor suppressor genes can lead to their silencing in many cancers. TSC-22 is a gene silenced in several solid tumors, but its function and the mechanism(s) responsible for its silencing are largely unknown. Here we demonstrate that the TSC-22 promoter is methylated in primar...

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Main Authors: Yu, Jianhua, Ershler, Maxim, Yu, Li, Wei, Min, Hackanson, Björn, Yokohama, Akihiko, Mitsui, Takeki, Liu, Chunhui, Mao, Hsiaoyin, Liu, Shujun, Liu, Zhongfa, Trotta, Rossana, Liu, Chang-gong, Liu, Xiuping, Huang, Kun, Visser, Jan, Marcucci, Guido, Plass, Christoph, Belyavsky, Alexander V., Caligiuri, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689053/
https://ncbi.nlm.nih.gov/pubmed/19329776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-205732
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