TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

Aberrant methylation of tumor suppressor genes can lead to their silencing in many cancers. TSC-22 is a gene silenced in several solid tumors, but its function and the mechanism(s) responsible for its silencing are largely unknown. Here we demonstrate that the TSC-22 promoter is methylated in primar...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Yu, Jianhua, Ershler, Maxim, Yu, Li, Wei, Min, Hackanson, Björn, Yokohama, Akihiko, Mitsui, Takeki, Liu, Chunhui, Mao, Hsiaoyin, Liu, Shujun, Liu, Zhongfa, Trotta, Rossana, Liu, Chang-gong, Liu, Xiuping, Huang, Kun, Visser, Jan, Marcucci, Guido, Plass, Christoph, Belyavsky, Alexander V., Caligiuri, Michael A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Hematology 2009
Θέματα:
Lymphoid Neoplasia
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689053/
https://ncbi.nlm.nih.gov/pubmed/19329776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-205732
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