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The tail binds to the head–neck domain, inhibiting ATPase activity of myosin VIIA

Myosin VIIA is an unconventional myosin, responsible for human Usher syndrome type 1B, which causes hearing and visual loss. Here, we studied the molecular mechanism of regulation of myosin VIIA, which is currently unknown. Although it was originally thought that myosin VIIA is a dimeric myosin, our...

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Main Authors: Umeki, Nobuhisa, Jung, Hyun Suk, Watanabe, Shinya, Sakai, Tsuyoshi, Li, Xiang-dong, Ikebe, Reiko, Craig, Roger, Ikebe, Mitsuo
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688991/
https://ncbi.nlm.nih.gov/pubmed/19423668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812930106
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