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Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines

It is generally assumed that amino acid mutations in the surface protein, hemagglutinin (HA), of influenza viruses allow these viruses to circumvent neutralization by antibodies induced during infection. However, empirical data on circulating influenza viruses show that certain amino acid changes to...

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Hlavní autoři: Ndifon, Wilfred, Wingreen, Ned S., Levin, Simon A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688967/
https://ncbi.nlm.nih.gov/pubmed/19439657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903427106
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