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Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines

It is generally assumed that amino acid mutations in the surface protein, hemagglutinin (HA), of influenza viruses allow these viruses to circumvent neutralization by antibodies induced during infection. However, empirical data on circulating influenza viruses show that certain amino acid changes to...

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Bibliografiske detaljer
Main Authors: Ndifon, Wilfred, Wingreen, Ned S., Levin, Simon A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688967/
https://ncbi.nlm.nih.gov/pubmed/19439657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903427106
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