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Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

Leukotrienes (LTs) are lipid mediators of inflammation formed by enzymatic oxidation of arachidonic acid. One intriguing aspect of LT production is transcellular biosynthesis: cells expressing 5-lipoxygenase (5LO) form LTA(4) and transfer it to cells expressing LTA(4) hydrolase (LTA(4)H) or LTC(4) s...

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Detalhes bibliográficos
Main Authors: Zarini, Simona, Gijón, Miguel A., Ransome, Aaron E., Murphy, Robert C., Sala, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688893/
https://ncbi.nlm.nih.gov/pubmed/19416808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903851106
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