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Drug efflux pump deficiency and drug target resistance masking in growing bacteria

Recent experiments have shown that drug efflux pump deficiency not only increases the susceptibility of pathogens to antibiotics, but also seems to “mask” the effects of mutations, that decrease the affinities of drugs to their intracellular targets, on the growth rates of drug-exposed bacteria. Tha...

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Bibliografski detalji
Glavni autori: Fange, David, Nilsson, Karin, Tenson, Tanel, Ehrenberg, Måns
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688851/
https://ncbi.nlm.nih.gov/pubmed/19416855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811514106
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