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Tumour maintenance is mediated by eNOS
Tumour cells become addicted to the expression of initiating oncogenes like Ras, such that loss of oncogene expression in established tumours leads to tumour regression1. HRas, NRas, or KRas are mutated to remain in the active GTP-bound oncogenic state in many cancers2. While oncogenic Ras activates...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688829/ https://ncbi.nlm.nih.gov/pubmed/18344980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06778 |
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